The Leonard D. Hamilton Collection is comprised of material relating to Hamilton’s contributions to James Watson, Francis Crick, and Maurice Wilkins's identification of the double helical structure of DNA which earned the Nobel Prize in Physiology or Medicine in 1962. The bulk of the collection pertains to Hamilton’s collaboration with Wilkins, to whom Hamilton was the primary supplier of DNA samples. The collection includes correspondence, laboratory notes, manuscript drafts, reprints, and photographs.